Cheapside House occupies a prominent position in the heart of the City of London, opposite St Paul's Cathedral and approximately 500 yards to the west of the Bank of England. It is situated on the north side of Cheapside, close to its junction with St Martin's Le Grand, New Change and Newgate Street.

The locality benefits from an extensive range of amenities, including the shops, restaurants, coffee bars, wine bars and public houses of two of the City’s premier retail streets, Bow Lane and Cheapside. The internationally acclaimed Paternoster Square is opposite.